In this context, TAM receptors (Tyro3, Axl, and Mer receptor tyrosine kinases) and corresponding ligands (GAS‐6 [growth arrest–specific 6], protein S) have been shown to be critically involved in hepatic immunomodulation and further are up‐regulated in patients with liver disease.(15, 16, 17) Accumulating evidence supports rather pleiotropic inhibitory effects on innate inflammatory responses.(18, 19, 20) Interestingly, TAM receptors are also involved in macrophage polarization. The gene discussed is GAS6; the disease is liver disorder.