Given the established association of TAM signaling and CLD, as well as its potential relevance in liver regeneration, we aimed to (1) explore whether preoperative soluble Axl (sAXL) and GAS‐6 levels could predict postoperative outcome after liver resection, (2) identify potential differences in their perioperative dynamics in patients with and without insufficient postoperative liver regeneration, and (3) gain mechanistic insight into how TAM signaling might affect liver regeneration in humans, particularly on the background of underlying liver disease. This evidence concerns the gene GAS6 and congenital secretory chloride diarrhea 1.