Like the overall numbers, the SRC location trended to be superior for PDX formation (Figure 3C,D) while only four established PDX in both anatomical locations (Figure 3E). For the HCC biopsies that formed PDX in both locations no differences in hAAT kinetics were observed (not shown). Given the small number of PDX lines, there was no clear pattern between HCC disease etiology and location. These data show that HCC biopsy material forms PDX at a 2‐fold higher rate under the renal capsule than in the liver, resulting in an overall 57% success rate in severely immunodeficient mice. This evidence concerns the gene SRC and hepatocellular carcinoma.