This would allow for easier PDX monitoring in non‐subcutaneous implantation sites such as intrahepatic (IH) or subrenal capsule (SRC). Serum from mice that were implanted with HCC biopsies were screened for several human markers including albumin (hAlb), α1‐antitrypsin (hAAT), transferrin, and α‐fetoprotein (hAFP). Here, ALB is linked to hepatocellular carcinoma.