On the other hand, eighteen heterozygous CELSR3 variants have been detected in patients with neuropsychiatric disorders, including thirteen cases with neural tube defects,12, 14, 17 two cases with developmental delay/intellectual disability,15, 18 two cases with Tourette syndrome,13 and one case with autism spectrum disorder19 (Table S1). This evidence concerns the gene CELSR3 and isolated spina bifida.