CELSR3 and neurodevelopmental disorder: Taken together that homozygous CELSR3 KO mice exhibited severe development abnormalities of the nervous system and neonatal death, it was possible that patients with homozygous CELSR3 variants of severe damage would be dead in early life, whereas patients with homozygous CELSR3 variants of less severe damage or with heterozygous CELSR3 variants of severe damage would present neurodevelopmental disorders, and patients with heterozygous CELSR3 variants of mild damage would present FS and/or epilepsy.