In addition, the Reactome pathway analysis indicated that particularly associated genes were classified in FGFR3 point mutants, constitutive signalling by aberrant PI3K, PI3K/AKT, NOTCH1 PEST domain mutants, NOTCH1, FGFR3 fusions, NOTCH1 HD + PEST domain mutants and ERBB2 in cancer, as depicted in Figure 9D. Here, NOTCH1 is linked to cancer.