ECM genes (eg, FBLN1 and FBLN2) also exhibited a pseudotime pattern in the human pan‐fibroblasts dataset, fibroblasts derived from patients with synpolydactyly (hand malformations) showed alterations in the level of FBLN1 splice variants,29 and ablation of Fbln2 in mice cardiac fibroblasts protected against progressive ventricular dysfunction, reducing the mortality after myocardial infarction.30 The gene discussed is FBLN1; the disease is myocardial infarction.