This is the method used on the test set in the benchmark analysis of the section “FAUST discovers predictive phenotypes in benchmark dataset” as well as in the validation analyses of “CD8+ T cells from virus-positive subjects correlate with in-tumor measurements; their association with outcome validates on independent data.” To apply it, an investigator must have a priori knowledge of the exact phenotype to evaluate. The gene discussed is CD8A; the disease is neoplasm.