PGR and neoplasm: In addition to VDR, several other nuclear receptors such as the estrogen‐related receptor (ERR), the progesterone receptor (PgR), the pregnane X receptor (PXR), and the constitutive androstane receptor (CAR) have been shown to influence CYP24A1 expression and/or activity.(9, 10, 11, 12) A recent study demonstrated that alcohol intake enhanced vitamin D catabolism in tumor‐bearing mice.(13) It has also been reported that CYP24A1 was translationally upregulated in breast cancer cells treated with supernatants of activated monocyte‐derived macrophages (to mimic tumor inflammation).