In addition to VDR, several other nuclear receptors such as the estrogen‐related receptor (ERR), the progesterone receptor (PgR), the pregnane X receptor (PXR), and the constitutive androstane receptor (CAR) have been shown to influence CYP24A1 expression and/or activity.(9, 10, 11, 12) A recent study demonstrated that alcohol intake enhanced vitamin D catabolism in tumor‐bearing mice.(13) It has also been reported that CYP24A1 was translationally upregulated in breast cancer cells treated with supernatants of activated monocyte‐derived macrophages (to mimic tumor inflammation). The gene discussed is NR1I2; the disease is breast cancer.