STAT3 and breast cancer: In vitro, 1,25D partially reversed the EMT phenotype (decreased invasion/motility) as evidenced by reduction in pSTAT3, ZEB1, and vimentin and increase in E‐cadherin.(21, 95, 96, 97, 98) Furthermore, dietary vitamin D inhibited EMT and lung metastasis via reduction in ZEB1 and STAT3 expression in the MMTV‐PyMT model of breast cancer.(21) In a xenograft model of human breast cancer, depletion of VDR promoted EMT and enhanced skeletal colonization.(23)