CYP24A1 and hypercalcemia disease: One interpretation of this profile is that it indicates hypersensitive transactivation of vitamin D–dependent genes as an underlying cause of the hypercalcemia, since CYP24A1 is the most upregulated gene in response to 1,25‐(OH)2D3 hormonal action, which is consistent with increased concentration of most metabolites formed by CYP24A1.