We explored the potential role of lncRNAs in VDR protection against skin tumor formation by profiling 90 well‐annotated mouse lncRNAs from mouse keratinocytes cultured in vitro and mouse epidermis from epidermal‐specific VDR null mice and their normal littermates.(67, 105) We found that several well‐known oncogenes, including H19, HOTTIP, and Nespas, are significantly increased, whereas tumor suppressor lncRNAs (Kcnq1ot1, lincRNA‐p21) were attenuated in VDR deleted keratinocytes. Here, VDR is linked to skin neoplasm.