The appearance of BCC in these studies was initially surprising because the typical malignancy induced in mouse skin by UVR, ionizing radiation, or chemical carcinogens is SCC, not BCC.(64) Given that BCC generally result from increased hedgehog (Hh) signaling(65) and that lack of VDR results in BCC when β‐catenin signaling is increased,(66) we became interested in the relationship between vitamin D, Hh, and β‐catenin signaling in tumor suppression. This evidence concerns the gene VDR and skin basal cell carcinoma.