The appearance of BCC is characteristic of tumors formed when Hh signaling is activated,(90) although activation of Hh signaling also predisposes to UVR‐induced SCC formation.(91)Vdr null animals overexpress elements of the Hh signaling pathway in their epidermis and the epidermal portion (utricles) of the hair follicles.(63) Moreover, 1,25(OH)2D suppresses the expression of all elements of the Hh pathway in a dose‐dependent fashion that requires the VDR(63, 92) and reduces tumor growth in Ptch 1 null mice. This evidence concerns the gene VDR and skin basal cell carcinoma.