Furthermore, dysregulation of local and circulating RAS, with increased ACE/Ang II expression levels and reduced ACE2/Ang‐(1‐7) expression levels, was reported to contribute to ischemia‐reperfusion‐induced acute lung injury (ALI) in mice.(79) Therefore, vitamin D may attenuate LPS‐induced ALI, at least partially, by inducing ACE2/Ang‐(1‐7) axis activity and inhibiting renin and the ACE/Ang II/AT1R cascade (Fig. 2B).(80) VDR activation is also able to inhibit the Skp2 protein,81, 82) which plays a pivotal role in the mechanism of viral replication in COVID‐19. This evidence concerns the gene REN and acute respiratory distress syndrome.