This increased CREB phosphorylation seems to be important in the early stages of skin tumor development in mice.(81) There is some evidence that the increased CREB phosphorylation after UV is at least, in part, downstream of increased ERK1/2 phosphorylation.(104) So the reduction in ERK1/2 phosphorylation after UV with1,25(OH)2D3, reported earlier,(36) may partly explain the reduced CREB‐phosphorylation after UV noted here. Here, CREB1 is linked to skin neoplasm.