Epithelial tight junction proteins also regulate intestinal barrier function.(29) A number of studies related to regulation by 1,25(OH)2D3/VDR of proteins involved in cell–cell adhesion have suggested an important role of VDR signaling to inhibit colitis by protecting against mucosal barrier dysfunction.(30, 31, 32, 33) Thus, it is possible that the primary role of 1,25(OH)2D3‐mediated regulation of intercellular adhesion molecules is not to mediate passive calcium absorption, but rather to enhance barrier function. Here, VDR is linked to colitis.