MTOR and polycystic ovary syndrome: However, new follow-up information on offspring of mothers with GDM or polycystic ovary syndrome (PCOS) have provided conflicting results since metformin has the potential to inhibit the primary nutrient sensor in the placenta (mTOR) and mitochondrial activity resulting in relative nutrient restriction that might adversely affect fetal growth and potentially increase the risk of childhood obesity when the offspring is exposed to an obesogenic environment [3].