IKZF1 and leukemia: Genetic and functional abnormalities of IKZF1, including deletion of a single Ikaros, were regarded as new prognostic indicators for high-risk leukemia in clinical trials (NCT00993538; NCT03709719, NCT01431664) (Mi et al., 2012; Tang et al., 2019; Granados-Zamora et al., 2020).