In some studies about certain solid tumors that lack IKZF1 expression, overexpression of Ikaros leads to increased immune recruitment infiltration and tumor sensitivity to cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1) inhibitors (Chen et al., 2015; Chen et al., 2018). Here, PDCD1 is linked to neoplasm.