In addition, the occurrence and maintenance of numerous human cancers, such as pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) (Churchman et al., 2018; Stanulla et al., 2018; Tayel et al., 2019), lung cancer (Li et al., 2014; Zhao et al., 2020), breast cancer (Edgren et al., 2011), nasopharyngeal carcinoma (Verhoeven et al., 2019), ovarian (He et al., 2012), liver (Liu et al., 2017), and colorectal cancer (Javierre et al., 2011), are also correlated with the abnormal expression of Ikaros family proteins. The gene discussed is IKZF1; the disease is precursor B-cell acute lymphoblastic leukemia.