In addition to increasing invasive and migratory ability in lung cancer cells through upregulation of the phosphatidylinositol-3 kinase (PI3K)/AKT/Twist axis induced by Aiolos overexpression, the overexpression of Aiolos also upregulates cancer stem cell-like properties through the same pathway (Hung et al., 2019). This evidence concerns the gene IKZF3 and lung carcinoma.