FOXO3 and hepatocellular carcinoma: Numerous studies have shown that miR-182-5p is dramatically overexpressed in HCC and could enhance the ability of migration, invasion, adhesion and proliferation of HCC cells via repressing multiple targeting genes, such as FOXO3a (21), Hepatitis C virus p7 trans-regulated protein 3 (P7TP3) (23), and regulator of calcineurin 1 (RCAN1) (24).