Indeed, osteosarcoma-derived extracellular membrane vesicles (EMVs) convey bioactive pro-osteoclastogenesis factors (as MMP-1 and -13, TGF-β, CD-9 and RANKL) responsible in stimulating osteoclast formation and bone resorption (Garimella et al., 2014). Here, MMP1 is linked to osteosarcoma.