MGMT and central nervous system cancer: To evaluate prognosis and develop therapeutic strategies, molecular biomarkers including O6-methylguanine-DNA methyltransferase (MGMT) methylation, codeletion of chromosome 1 and 19 (1p/19q), mutations in isocitrate dehydrogenase (IDH) are under active investigation in patients with glioma (Molinaro et al., 2019).