TRIM63 and cancer: Such unresponsiveness of MuRF1 mRNA and protein to a cancer burden was previously observed in cachectic cancer patients (Gallagher et al., 2012; Stephens et al., 2010; D'Orlando et al., 2014; Op den Kamp et al., 2013), despite observations of MuRF1 upregulation in some murine cancer models (Zhou et al., 2010; Roberts et al., 2013; Talbert et al., 2014).