The Hsp70/90—TLR4—p38β MAPK—p300—C/EBPβ signaling pathway is activated in diverse types of murine cancer models including Lewis lung carcinoma (Zhang et al., 2011; Zhang and Li, 2012; Zhang et al., 2013; Zhang et al., 2017a; Zhang et al., 2017b; Liu et al., 2018; Sin et al., 2019a), Apcmin/+ mice bearing intestinal adenocarcinoma (Zhang et al., 2017a) and nude mice bearing human AsPC-1 pancreatic ductal adenocarcinoma (Yang et al., 2019). Here, TLR4 is linked to pancreatic ductal adenocarcinoma.