NF-κB-mediated HIF-1α, or vice versa, has been extensively documented in various conditions, including malignant lymphoma and immune responses (Rius et al., 2008; Van Uden et al., 2008; Qiao et al., 2010; Remels et al., 2015; D’Ignazio et al., 2016). The gene discussed is HIF1A; the disease is lymphoma.