Methylselenopyruvate is an α-keto acid metabolite of methylselenocysteine which acts as a histone deacetylase 8 (HDAC8) inhibitor that can restore Bcl2 modifying factor (BMF) downregulation and thereby activates apoptosis in colon cancer cells (25). This evidence concerns the gene HDAC8 and malignant colon neoplasm.