IL6 and periodontal disorder: However, an increased recognition for the potential influence of periodontal disease as a contributory mediator in Alzheimer’s is increasingly recognized, such as via an increase in pro-inflammatory mediators, such as C-reactive protein (CRP), IL-6, IL-1β, and TNF-α, that may contribute to synapoptoxic β-amyloid and neurofibrillary fiber tangle deposition (Gaur and Agnihotri, 2015).