It is well-known that activation of mTORC1 facilitates phosphorylation of p70-S6 kinase (S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), two factors that engage in protein synthesis, and accelerate HCC proliferation (93). The gene discussed is EIF4EBP1; the disease is hepatocellular carcinoma.