For solving these puzzles, GP73-interacted proteins were identified using coimmunoprecipitation combined with LC-MS/MS, and epithelial growth factor receptor (EGFR) was identified as a critical GP73-interacted factor in HCC cells, which interacts with GP73 via the cytoplasmic domain of GP73 (17, 111, 112). The gene discussed is GOLM1; the disease is hepatocellular carcinoma.