Following studies have focused on the mechanisms of how GP73 facilitates cancer metastasis, and they have discovered that highly expressed GP73 upregulates the levels of N-cadherin, vimentin, and MMP-13 in HCC cells, which prove that GP73 surely serves as a multifunctional factor modulating the expression of EMT-related proteins (Table 4). Here, GOLM1 is linked to hepatocellular carcinoma.