In a pioneering study, with the help of laser-capture tissue microdissection and genome-wide cDNA arrays technologies, GOLM1 was identified as a leading gene significantly upregulated in tumor tissues from HCC patients with extrahepatic metastases (EHMH) but not in tissues from metastasis-free HCC (MFH) patients, which suggests that GP73 is a critical factor modulating cancer metastasis (17). This evidence concerns the gene GOLM1 and hepatocellular carcinoma.