Synergistic inhibition of KDM6B and KDM1A by GSK-J1 and TCP in vivoInhibiting cancer cell proliferation, and particularly exhibiting an inhibitory effect in vivo in PDX model of acute myeloid leukemia, breast cancer, T-cell acute lymphoblastic leukemia, colorectal cancer and osteosarcoma. The gene discussed is KDM6B; the disease is breast cancer.