KDM6B is upregulated via nuclear factor-κB (NF-κB) binding to its promotor region by tumor necrosis factor α (TNFα), and that KDM6B in turn upregulates mitogen-activated protein kinase (MAPK) pathway, thereby promoting cancer cell growth and survival in a catalytically-independent manner (Figure 3) (27, 28). Here, KDM6B is linked to cancer.