KDM6B could promote the invasion of hepatocellular cancer, non-small cell lung cancer, renal cell cancer and chordoma through upregulation of EMT-specific genes, such as TIAM1, E-cadherin, SNAI1 and TBXT (101, 112, 113, 115, 116). The gene discussed is KDM6B; the disease is hepatocellular carcinoma.