NPM1 and myeloproliferative disorder: UPN09 (Figures 1D, 2) was diagnosed with secondary AML (prior diagnosis of myeloproliferative neoplasm (MPN); AML not otherwise specified (NOS), AML without maturation, normal male karyotype, no BCR–ABL1 fusion, no CEBPA, FLT3, or NPM1 mutation) in 2008.