When insulin resistance appears, it also leads to endothelial dysfunction through the impairment of nitric oxide production and the inhibition of insulin-induced vasorelaxation; eNOS function impairment has been widely associated with it. Moreover, it was demonstrated that endothelial dysfunction with impaired nitric oxide production is involved in the progression of advanced liver diseases such as cirrhosis. The gene discussed is INS; the disease is endothelial dysfunction.