SPAST and hereditary spastic paraplegia: We report the case of a 27-year-old pregnant Chinese woman with HSP in whom we identified a missense mutation in the SPAST gene (c.1496G>A, p.Arg499His) and a nonsense mutation in the NEFH gene (c.289G>T, p.Glu97∗) via whole-exome sequencing; this finding corroborated that of Sanger sequencing.