LSM12 is highly expressed in the exosomes of cancer tissues, and because it is negatively correlated with CD4 + T cells in the tumor microenvironment, it will cause the level of CD4 + T cells in the tumor microenvironment to be reduced, affecting T, M, N, and stage of CRC, which may promote CRC transfer. The gene discussed is CD4; the disease is colorectal carcinoma.