We then analyzed mRNA expression levels in CRC tumors and normal tissues (Figure 6); we found that compared with normal tissues, SIK1 (p=0.007), ARPC1B (p=0.018), PGAM1 (p=0.006), GOLGA8A (p=0.001), GOLGA8B (p=7.082e − 04), HNRNPA3 (p=0.047), SERF1A (p=4.011e − 05), UBC (p=7.082e − 04), SPCS2 (p=0.034), RGPD6 (p=8.884e − 07), NOMO3 (p=6.538e − 05), LSM12 (p=9.098e − 05), RGPD5 (p=3.746e − 06), HSPA1B (p=1.5133 − 06), and MYL6 (p=0.002) all had significantly higher expression in tumor tissues. This evidence concerns the gene SPCS2 and neoplasm.