Also, WCE rich in flavonoids suppressed IL-6, CXCL1, and CXCL8 thus reducing tumor-elicited infiltration MDSCs, TAMs, and endothelial cells accompanied by reduced STAT3 activation, in MDSCs in PC-3 and DU145 prostate cancer xenografts. The gene discussed is CXCL1; the disease is neoplasm.