TNF and cancer: In this regard, flavonoids are anti-inflammatory agents that downregulate crucial modulators of advanced stages of cancer such as IL-1β, IL-6, IL-10, TNF-α, NF-κβ, NOS2, PTGS2, PTGER2, ACAN, COL2A1, MMP1, MMP13, ADAMTS4, ADAMTS5, and TIMP1.