NKX2-1 and thyroid gland papillary carcinoma: As early as 2009, Gudmundsson et al. firstly pointed out that variants on 9q22.33 (FOXE1) and 14q13.3 (NK2 homeobox 1 (NKX2-1)) might increase the risk of papillary thyroid cancer and follicular thyroid cancer [2].