The analyses detected significantly elevated POLE expression levels in ccRCC compared with normal samples in the Gumz Renal (n = 10; p = 0.043), Cutcliffe Renal (n = 14; p = 0.011), Lenburg Renal (n = 9; p = 0.006), and Jones Renal (n = 23; p = 0.035) cohorts (Figures 1B–E). This evidence concerns the gene POLE and nonpapillary renal cell carcinoma.