POLE expression was closely linked with OS in many cancers such as Adrenocortical carcinoma (ACC) (hazard ratio (HR) = 3.96; p = 1.3e−06), Brain Lower Grade Glioma (LGG) (HR = 1.97; p = 8.4e−08), and Skin Cutaneous Melanoma (SKCM) (HR = 1.37; p = 0.0032); and DSS in ACC (HR = 3.82; p = 5.2e−06), LGG (HR = 2.01; p = 1.0e−07), Mesothelioma (MESO) (HR = 3.48; p = 3.9e−05), and Kidney Chromophobe (KICH) (HR = 12.55; p = 2.6e−05). The gene discussed is POLE; the disease is cutaneous melanoma.