In the univariate analysis for OS using gender (male or female), ECOG score, treatment line number (≤2 or ≥3), AFP level (<400 or ≥400), number of tumors (<3 or ≥3), TNM (III or IV), metastatic status (Yes or No), and irAEs status (non-irAE group or irAE group) as covariates in ICI-treated HCC, clinical characteristics including PS > 1, ≥3 treatment line, TNM (IV), AFP ≥ 400, and tumor metastasis were significantly associated with shorter OS at statistical levels. Here, AFP is linked to neoplasm.