In order to verify the key extracellular proteins identified, 51 RRMS patients and 20 patients with primary headache who excluded CNS infectious diseases and recent infections were included (see Tables 3,  4 and Supplementary Material 10 for patient baseline data), and the patients’ CSF was collected to detect IL17A, Del-1 (encoded by the EDIL3 gene) levels. Here, EDIL3 is linked to infection.