Pathway analyses of these proteins indicated an enrichment of the protein pathways “HSA-5663205: infectious diseases” and “HSA-168254: influenza infection” (Figure 3B and Supplementary Table 3), which included proteins implicated in viral mRNA and protein synthesis (e.g., ribosomal proteins RPS16, RPLP0, or RPS15), highlighting a potential protective effect of imiquimod against viral infections. This evidence concerns the gene RPS16 and viral infectious disease.