PROS1 and coinfection: In addition, co-infection of PEDV variants with 214 amino acid deletion in the S protein and PEDVs with an intact S protein in the lungs of naturally infected pigs has been found recently, thereby suggesting that PEDV targets epithelial cells and submucosal glands of the airway tract, epithelial cells of the bile duct, and monocytes/macrophages (Van Diep et al., 2020).