In line with reduced gene expression of VIRMA in patients with obesity, we find in SAT gene expression of VIRMA correlated to BMI (P=0.021), waist to hip ratio (WHR) (P=0.012), percentage of body fat (P=0.0003), maximal adipocyte diameter in SAT (P=0.009) and OVAT (P=0.011), and leptin serum levels (P=0.016). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.