MKI67 and neoplasm: HE staining showed that the combination of sorafenib and BD and sorafenib high dose treatment could significantly induce tumor tissue necrosis, TUNEL showed that the combination group and sorafenib high dose group could significantly induce the apoptosis of hepatoma tumor cells, and Ki67 showed that the combination group and sorafenib high dose group could significantly inhibit the proliferation of hepatoma tumor cells (Figure 6C).