Ginsenoside Rg3 could down-regulate DNA methyltransferase DNMT3A and decrease the methylation in the promoter region of miR-519a-5p precursor gene, thus upregulating miR-519a-5p to inhibit the HIF-1α-stimulated Warburg effect in ovarian cancer (Lu et al., 2020). This evidence concerns the gene HIF1A and ovarian carcinoma.