In vitro experiments with Jurkat T cells demonstrated that JP upregulated the levels of DNA methylation, MeCP2 mRNA, and protein as effectively as prednisone acetate, and thus may activate the MeCP2 gene by increasing the methylation level, thereby inhibiting the pathogenesis of SLE (Li R. et al., 2018). Here, MECP2 is linked to systemic lupus erythematosus.