Some enriched pathways in SS tears include leukocyte transendothelial migration (CTSB, ITGB2, MMP9), protein-lipid complex remodeling (PSAP, PLTP, APOE, MPO) and collagen catabolic process (CST3, VIM, MMP8, TGM2, ITGB2, MMP9, CTSB) (Figure 1B, Supplementary Table S1). Here, MMP8 is linked to synovial sarcoma.