In addition, NF-κB signaling pathways, involved into inflammatory responses in the pathogenesis of RA (Bondeson et al., 1999; Tak et al., 2001), can also be activated in myeloid cells when TLR7/8 agonists bind to their receptors, and the subsequent cytokines production are cell-type dependent (Eng et al., 2018). This evidence concerns the gene TLR7 and rheumatoid arthritis.