For example, lidocaine increases the sensitivity of breast cancer cells to tamoxifen by down-regulating the expression of GOLT1A, which enhanced prognosis (Zhang et al., 2017), Lidocaine also enhances the toxicity of the cancer drugs mitomycin C, pirarubicin, softening lotion and cisplatin (Sui et al., 2019; Gong et al., 2018). This evidence concerns the gene GOLT1A and breast carcinoma.