RHOA and gastric cancer: Some studies showed that sodium channel blockade contributed to the anticancer activity of LAs (Fraser et al., 2014), but these studies also demonstrated that bupivacaine inhibited the migration of gastric cancer cells via the sodium-independent channel blocker RhoA and NET1 inhibition (Dan et al., 2018; Zheng et al., 2020; Pang et al., 2021).