Several studies have shown that MFGE8 is a novel anti-inflammatory factor in multisystem diseases, such as neonatal sepsis, hepatic steatosis, rheumatoid arthritis and kidney injury (Albus et al., 2016; Hansen et al., 2017; Zhao et al., 2019; Zhang et al., 2021). This evidence concerns the gene MFGE8 and Hepatic steatosis.