GFAP and Alexander disease: In addition, autophagy-mediated mutant protein elimination and sHSPs-mediated refolding are considered druggable molecular targets, whose modulation, in in vivo and in vitro experimental model of AxD, has been documented to result in the rescue of filamentous mutant GFAP patterns (Bachetti et al., 2010a; Bachetti et al., 2012).