According to most of the studies, the critical genes for PCOS development were not reported yet, but scholars are in agreement with INSR, IRS1-2, MTNR1A, MTNR1B, THADA, PPAR-γ2, ADIPOQ, and CAPN10 as more susceptible genes in PCOS incidence. The gene discussed is INSR; the disease is polycystic ovary syndrome.