Atrial natriuretic peptide (ANP), a cardiovascular hormone mainly secreted by the heart atria [16], plays obvious protective roles in a variety of diseases (ventricular hypertrophy, myocardial injury, hypertension, tumor, acute lung injury, cerebral ischemia/reperfusion injury, and sepsis, etc.)[17–27]. This evidence concerns the gene NPPA and cardiac hypertrophy.