PRRT2 and Hyperglycemia: Although GSH level is not reduced in diabetic patients since it is likely to be maintained by the NADPH supplied by the normal G6PD, hyperglycemia can promote ROS accumulation through activation of multiple metabolic pathways: (1) increased flux of glucose through the polyol pathway, (2) increased formation of advanced glycation end products (AGEs), (3) activation of protein kinase C (PKC), and (4) increased hexosamine pathway flux [4].