This is supported by a previous study in which perineural administration of both saporin-conjugated anti-Mac1 antibodies and TC-25594-[(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate], an nAChR agonist capable of inhibiting macrophages, reduced neuropathic pain in a high fat diet T2DM model [14]. The gene discussed is CHRNA4; the disease is type 2 diabetes mellitus.