Research shows that physical exercise can reverse part of these obesity-related pathologies by decreasing the availability of free fatty acids and improving the insulin sensitivity of glucose metabolism [29], reducing hypertension [30], decreasing arterial stiffness [31], reducing both fibrinogen and fibrinolytic biomarkers [32], relieving arthritis [33,34], and improving menstrual issues [35]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.