Compared with the CC genotype, at least G genotype (CG and GG) allele on WWOX rs3764340 also enhanced the risk of the tumor status, including the size of the primary tumor and the invasion of adjacent tissues in patients with EGFR L858R mutation (OR = 3.681, 95% CI = 1.259–10.757, p = 0.014; Table 4). Here, EGFR is linked to neoplasm.