ACE and immune system disorder: Furthermore, we found no association between numerous medical conditions and risk of VTE, including cerebrovascular disease [21,35], chronic kidney disease [15,19,21,25,26,28,31,35], chronic respiratory disease—including asthma and COPD [15,19,21,25,26,28,29], diabetes mellitus [15,17,19,21,25,26,27,28,29,31,32,35], hypertension [15,17,19,21,26,27,28,29,32,35], immunodeficiency [15,25,28], and use of ACE inhibitors [19,29].