In exercise-trained two kidney-1 clip hypertensive rats Ang 1-7 administration reduces hypertension, myocardial fibrosis and hypertrophy [22], while in diabetic mice ameliorates diabetic cardiomyopathy and diastolic dysfunction by reducing lipotoxicity and inflammation [23] and prevents cardiac fibrosis in Doca-salt hypertension [24]. Here, ANGPT1 is linked to Myocardial fibrosis.