In fact, activation of AT2 receptors improves cardiac function in rat with myocardial infarction [13,14], prevents the development of myocardial hypertrophy in type 2 diabetic rats [15], vascular stiffness in an experimental model of N-nitro-l-arginine-methyl ester-induced hypertension [16], myocardial fibrosis in stroke-prone spontaneously hypertensive rats [17], salt induced myocardial hypertrophy in Wistar rats [18], and reduces myocardial fibrosis in experimental model of cyclosporine nephropathy [19]. The gene discussed is AGTR2; the disease is Myocardial fibrosis.